DescriptionArtificial Intelligence (AI) has the opportunity to change the prevention and treatment of heart disease. Heart attack frequently strikes without warning and even expert cardiologists cannot tell, which of the potentially many initially small coronary plaques that almost invariably exist in all humans starting at their 2nd decade of life will remain stable. A small number of plaques will rupture, and even cause a heart attack. Optical coherence tomography (OCT) imaging depicts plaque tissue at an unprecedented level of detail. Our approach employs deep learning to localize and quantify existing plaques and predict future plaque vulnerability using OCT image data. For heart disease treatment, we developed a mixture that can be injected to repair the heart after a myocardial infarction. We used a novel device that leverages AI to replicate transplanted cellular secretions. From these replicated secretions, we create a mixture that can be used to repair injured cardiac cells.